Neoadjuvant treatment is treatment given as a first step to shrink a tumor before the main treatment e.g. surgery or radiotherapy.
In her 2016 paper on this theme Dr Lisa Loughney noted that neoadjuvant cancer treatment decreases physical fitness and low levels of physical fitness are associated with poor surgical outcome. She added that exercise training can stimulate skeletal muscle adaptations, such as increased mitochondrial content and improved oxygen uptake capacity that may contribute to improving physical fitness. She has therefore evaluated the evidence in support of exercise training in people with cancer undergoing the “dual hit” of neoadjuvant cancer treatment and surgery.
Dr Loughney works in the National Institute of Health Research’s Respiratory Biomedical Research Unit at the University Hospital of Southampton’s NHS Foundation Trust.